The novel follows a vivid narration of the life of a German composer named Adrian Leverkühn, by his old friend Serenus Zeitblom who happens to be a doctor of philosophy. Adrian, born in 1883, graduated from Kayzersasherna and went on to graduate university, finally becoming a teacher of classical languages and acquiring a family.
In the story, Zeitblom is two years older than Levedrkün, the latter spending his childhood in the estate of his father near Kayzersashern. If the lifestyle of Levedrkün is looked at, integrity and a strong commitment to family values and traditions can be observed.
Adrian is seen to live with his uncle who maintains a music store in the same city where he goes to high school. Although Adrian possesses an astounding record in school in terms of academic success, he is found to have a slight arrogance and secretive nature embodied within him for which he likes to maintain his privacy.
At fourteen years old Adrian is occupied with music and on the exhortation of his uncle starts to take lessons from Wendell Kretzschmar, an artist.
Subsequent to completing secondary school, Adrian goes on to study at the University of Halle, focusing on Theology, where Zeitblom moved as well. There the instructor of Shlepfus’s religion of psychology shows his understudies the hypothesis of demonic presence and real magic existing in the living world. As he watched Adrian from the perspective of the public eye in around the same time Zeitblom is progressively persuaded of his strange nature.
Leverkühn works on keeping up his relationship with Kretzschmar, and as the latter is welcomed in the Leipzig Conservatory, he follows suit. He got disappointed and outright baffled by Theology, and thus is currently studying Philosophy, yet he tends increasingly more to music.
Upon Adrian’s arrival in Leipzig, rather than to a motel, he is brought to a brothel instead. A young lady approaches Adrian who is said to have almond-shaped eyes and attempts to pat his cheek, as he surges away. From that point forward, her thought occupies his mind, and he waits for a whole year to go and look for her. The man goes to Bratislava, yet when Adrian at long last discovers the girl he has been looking for all along, she cautions that she is debilitated with syphilis; still, he demands intimacy from her. On the other side, Adrian restarts his initial classes in Leipzig, however soon he is compelled to look for therapeutic treatment. However, an end to his treatment is not brought with the doctor he was assigned who passes away all of a sudden. Attempting to look for a new specialist likewise deems unsuccessful, as the specialist was arrested. Hence, the young man chooses not to look for any more doctors.
He begins to focus more on his work passionately and energetically. The most crucial part of his project in the stated time period was a melody cycle by Brentano. Leverkühn gets to know an artist and translator named Schieldknapp in Leipzig, who influences him in making musical drama lyrics to "Vain endeavors of affection," one of Shakespeare's noteworthy plays.
Kretzschmar is offered chief conductor in 1910 at a theater in Lyubeksk and Leverkühn follows him, where Leverkühn shifts into a small room adjacent to a Senator named Roddy’s widow who lives with two of her grown-up little girls – Clarissa and Inese. Local parties are frequently organized, and Adrian gets to meet new people all around. He is acquainted with one particular man, an exceptionally talented Rudolf Schverdtveher who is a violinist. He frequently seeks Adrian’s attention and companionship. Before long, Schieldknapp follows Adrian and moves to Munich.
In search of solace which he did not seem to find in Munich, Leverkühn moves to Italy with Schieldknapp. They spend their times in Palestrina, a small village adjacent to the mountains, in the hot summer weather. At the place, they come to know Tseytblom. As Adrian buckles down on the musical show, Tseytblom discovers his music to have a great degree of strangeness and imaginative prowess.
Here, a sequence of interesting incidents happens with Leverkühn, which is uncovered in Leverkühn’s melodic notebook which is written by Serenus Zeitblom. He is visited by the devil himself and confesses regarding Adriana and her secret illness along with steady attention regarding Leverkühn’s destiny. According to the devil, when Adrian was purposely tainting himself with the revolting sickness, he made an arrangement with the powers of malevolence from that point forward and one day Satan will call him in twenty-four years. Be that as it may, one specific condition stands: He should surrender love until the end of time.
In the pre-winter of 1912, Adrian takes up space in a house close to Munich after the two companions return from Italy, which was always in his mind amid his walks across the country. This place helps him remember his folks’ ranch. Here on, he begins to come close to his companions and colleagues from Munich.
Following the aforementioned incidents, we see Leverkühn again starts to enjoy writing a handful of vocal pieces. They aren’t open to the masses, but rather are showcased in numerous German Philharmonic theatres, bringing the creator a distinction of fame. He composes an ensemble in 1914 coined as "Wonders of the Universe." The beginning of the World War does not influence Leverkühn, as he keeps on working harder than ever, simultaneously enjoying his stay in the mansion.
In the meantime, Inese Roddy gets married to Ynstytorys, a Professor, in spite of having undivided love towards Schverdtveher, confessing her inner emotions to the author herself. Clarissa, her sister, additionally abandons her local town to committing herself, and Mrs. Roddy eventually leaves and ends up settling near Leverkühn, who around then begins to deal with the oratorio "End times." He needs to demonstrate to humankind the element which he approaches with his demonic music.
Clarissa Roddy comes back to her mom in the spring of 1922. Having experienced the imaginative crumple and fiasco she seeks personal happiness and ends up by drinking poison, ultimately taking her life.
Schverdtveher is tuned into by Leverkühn and devotes a show to the man himself, which can be coined as a noisy achievement. The performance is again repeated, as Rudolf and Adrian get to know Marie Rotsi, a theater artist, which takes place in Zurich. A couple of months after the fact she arrives in Munich, a couple of days after the violinist requests that Leverkühn help with making their marriage work. He reluctantly concurs and concedes that even he is partially enamored. After two days of the incident, everyone officially gets to know about Rudolf and Marie’s engagement. It seems that the wedding will take place in the same place the violinist has another agreement in; Paris. In any case, in transit from his goodbye show, he meets in passing Inese Roddy in Munich who in an attack of envy kills him shooting in the tram.
After a year passing since the catastrophe, "Apocalypse" at long last is performed. The show is a breathtaking achievement, yet by ideals of a profound true tragedy, the author himself is absent. The composer keeps on creating noteworthy chambers simultaneously developing "Cry of Doctor Faustus”, with the arrangement of the cantata.
During late spring of 1928, Leverkühn goes to his nephew who happens to be five years old and starts staying with him. Adrian gets attached to the beguiling and delicate child wholeheartedly. In any case, the kid falls sick in light of meningitis within two months, and in a couple of days passes away with the doctors’ hands tied.
The following two years, Leverkühn dedicates himself to intensive creative activities. He welcomes companions and associates to hear his new work in May 1930. Around thirty visitors come, and after that, he admits that everything he made in the last twenty-four years was actually the work Satan had a role to play in. His unconstrained endeavors to damage the forbiddance of adoration (fellowship with a youthful violinist, means to wed the blameless kid) prompt them passing away, which is the reason he not only sees himself as both as an executioner and a sinner. A large portion of the visitors takes off.
Leverkühn starts playing the piano, tumbles to the floor, then comes to with indications of frenzy and sheer madness when he wakes up. Following facility treatment for three months, his mom takes him home, caring for him afterward like he was a little kid. In 1935, at the point when Zeitblom comes to praise a companion on a commemoration having its fiftieth year, he doesn't remember him, only to leave the worldly life after just five years.
The story interchanges with creator's views regarding contemporary Germany in his notes, emotional contentions about the disastrous destiny "of a monster nation," the unavoidable fall of countries which choose to place over the whole world; the creator reviles that power which wrecked its own kin under the mottos of its success.